Sporadic cerebral non-amyloid microangiopathy: pathogenesis, diagnosis, and features of treatment policy

Abstract

The paper is devoted to the most common variant of cerebral small-vessel disease Р sporadic cerebral non-amyloid microangiopathy (SCNAMA) in the context of acute and chronic cerebral circulatory disorders. It highlights the topical issues of neuropathology and pathogenesis of the disease. The paper presents the current neuroimaging markers of SCNAMA with a detailed discussion of lacunar infarcts, cerebral microinfarctions, and microbleeds. It considers the clinical manifestations of the chronic form of the disease, including cognitive impairment. The problem in the differential diagnosis of SCNAMA and cerebral amyloid angiopathy is highlighted. The current possibilities of minimizing risks and improving the efficiency of treatment in this category of patients are discussed.

Keywords

• cerebral small-vessel disease
• cerebral non-amyloid microangiopathy
• lacunar infarct
• cerebral microinfarction
• vascular cognitive impairment