Nature Communications (Mar 2023)

The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice

  • Jimena L. Frontera,
  • Romain W. Sala,
  • Ioana A. Georgescu,
  • Hind Baba Aissa,
  • Marion N. d’Almeida,
  • Daniela Popa,
  • Clément Léna

DOI
https://doi.org/10.1038/s41467-023-36943-w
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 16

Abstract

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Fear extinction is a learning process controlled by the prefrontal cortex. Here, authors show that the cerebellum regulates fear extinction via projections to the medio-dorsal thalamus and the modulation of thalamo-prefrontal cortex interactions.