BMC Cancer (Jul 2007)

Polymorphisms in the cytochrome <it>P</it>450 genes <it>CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1</it>, <it>CYP19A1 </it>and colorectal cancer risk

  • Withey Laura,
  • Penegar Stephen,
  • Rudd Matthew,
  • Sellick Gabrielle,
  • Webb Emily,
  • Bethke Lara,
  • Qureshi Mobshra,
  • Houlston Richard

DOI
https://doi.org/10.1186/1471-2407-7-123
Journal volume & issue
Vol. 7, no. 1
p. 123

Abstract

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Abstract Background Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones. Methods To investigate if common variants of CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1 and CYP19A1 influence CRC risk we genotyped 2,575 CRC cases and 2,707 controls for 20 single nucleotide polymorphisms (SNPs) that have not previously been shown to have functional consequence within these genes. Results There was a suggestion of increased risk, albeit insignificant after correction for multiple testing, of CRC for individuals homozygous for CYP1B1 rs162558 and heterozygous for CYP1A2 rs2069522 (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.03–1.80 and OR = 1.34, 95% CI: 1.00–1.79 respectively). Conclusion This study provides some support for polymorphic variation in CYP1A2 and CYP1B1 playing a role in CRC susceptibility.