International Journal of Ophthalmology (Oct 2013)

Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy

  • Orhan Ates,
  • Habip Bilen,
  • Sadullah Keles,
  • H. Hakan Alp,
  • Mevlüt Sait Keleş,
  • Kenan Yıldırım,
  • Osman Öndaş,
  • L. Can Pınar,
  • Mustafa Civelekler,
  • Orhan Baykal

DOI
https://doi.org/10.3980/j.issn.2222-3959.2013.05.24
Journal volume & issue
Vol. 6, no. 5
pp. 675 – 679

Abstract

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AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group (n=50). The control group was consist of healthy individuals (n=50). Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups.RESULTS: Ubiquinone-10 (Coenzyme Q10) levels in PDRP and control subjects are 3.81±1.19µmol/L and 1.91±0.62µmol/L, respectively. Plasma MDA levels in PDRP and control subjects were 8.16±2µmol/L and 3.44±2.08µmol/L, respectively. Ratio of Ubiquinol-10/ubiquinone-10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68, respectively.CONCLUSION:The ratio of ubiquinol-10/ubiquinone-10 is found lower in patients with PDRP. High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.

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