Biomedical Photonics (Sep 2017)
PHOTOSENSITIZERS AS RADIOSENSITIZING AGENTS IN EXPERIMENTAL AND CLINICAL NEUROONCOLOGY
Abstract
The article summarizes the main mechanisms underlying the radiosensitizing effect of photosensitizers.According to literature data many authors consider the formation of reactive oxygen species to be the key element in the implementation of the antitumor effect of ionizing radiation, which transfers the photosensitizer molecule from the ground state to the excited state. Their formation leads to the development of oxidative stress. The consequence of the realization of the oxidative stress induced by ionizing radiation is apoptosis of tumor cells.The first photosensitizers, which radiosensitizing activity was confirmed, were hematoprofyrin and photophryn II. A detailed analysis of the results of experimental studies of radiosensitizing effect of photosensitizers on cell culture and laboratory animals with transplanted lines of malignant gliomas (glioma C6, gliosarcoma 9L, glioblastoma U87-MG) was made.The method of tumor radiosensitizing by administration of photosensitizers has been tested in patients with recurrent gliomas grade III-IV in a number of oncological centers. The obtained results show its good tolerability and antitumor efficacy.We have not found publications on the study of the radiosensitizing effect of chlorine-based photosensitizers in the available literature, that makes following studies in this field relevant.
