Nature Communications (Apr 2017)
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
- Feng Xie,
- Ke Jin,
- Li Shao,
- Yao Fan,
- Yifei Tu,
- Yihao Li,
- Bin Yang,
- Hans van Dam,
- Peter ten Dijke,
- Honglei Weng,
- Steven Dooley,
- Shuai Wang,
- Junling Jia,
- Jin Jin,
- Fangfang Zhou,
- Long Zhang
Affiliations
- Feng Xie
- Life Sciences Institute and Innovation Center for Cell Signalling Network
- Ke Jin
- Life Sciences Institute and Innovation Center for Cell Signalling Network
- Li Shao
- State Key Laboratory for Diagnostic and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease
- Yao Fan
- Life Sciences Institute and Innovation Center for Cell Signalling Network
- Yifei Tu
- Life Sciences Institute and Innovation Center for Cell Signalling Network
- Yihao Li
- Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600 2300 RC Leiden, The Netherlands
- Bin Yang
- Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco
- Hans van Dam
- Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600 2300 RC Leiden, The Netherlands
- Peter ten Dijke
- Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600 2300 RC Leiden, The Netherlands
- Honglei Weng
- Department of Medicine II, Medical Faculty Mannheim, Heidelberg University
- Steven Dooley
- Department of Medicine II, Medical Faculty Mannheim, Heidelberg University
- Shuai Wang
- Institutes of Biology and Medical Science, Soochow University
- Junling Jia
- Life Sciences Institute and Innovation Center for Cell Signalling Network
- Jin Jin
- Life Sciences Institute and Innovation Center for Cell Signalling Network
- Fangfang Zhou
- Institutes of Biology and Medical Science, Soochow University
- Long Zhang
- Life Sciences Institute and Innovation Center for Cell Signalling Network
- DOI
- https://doi.org/10.1038/ncomms15021
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xieet al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis.
