Synthetic zwitterions as efficient non-permeable cryoprotectants

Yui Kato; Takuya Uto; Daisuke Tanaka; Kojiro Ishibashi; Akiko Kobayashi; Masaharu Hazawa; Richard W. Wong; Kazuaki Ninomiya; Kenji Takahashi; Eishu Hirata; Kosuke Kuroda

doi:10.1038/s42004-021-00588-x

Communications Chemistry (Oct 2021)

Synthetic zwitterions as efficient non-permeable cryoprotectants

Yui Kato,
Takuya Uto,
Daisuke Tanaka,
Kojiro Ishibashi,
Akiko Kobayashi,
Masaharu Hazawa,
Richard W. Wong,
Kazuaki Ninomiya,
Kenji Takahashi,
Eishu Hirata,
Kosuke Kuroda

Affiliations

Yui Kato: Faculty of Biological Science and Technology, Institute of Science and Engineering, Kanazawa University
Takuya Uto: Organization for Promotion of Tenure Track, University of Miyazaki
Daisuke Tanaka: Genetic Resources Center, National Agriculture and Food Research Organization, Kannondai
Kojiro Ishibashi: Cancer Research Institute, Kanazawa University
Akiko Kobayashi: Cell-Bionomics Research Unit, Institute for Frontier Science Initiative
Masaharu Hazawa: Cell-Bionomics Research Unit, Institute for Frontier Science Initiative
Richard W. Wong: Cell-Bionomics Research Unit, Institute for Frontier Science Initiative
Kazuaki Ninomiya: Institute for Frontier Science Initiative, Kanazawa University
Kenji Takahashi: Faculty of Biological Science and Technology, Institute of Science and Engineering, Kanazawa University
Eishu Hirata: Cancer Research Institute, Kanazawa University
Kosuke Kuroda: Faculty of Biological Science and Technology, Institute of Science and Engineering, Kanazawa University

DOI: https://doi.org/10.1038/s42004-021-00588-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 10

Abstract

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Zwitterionic solutions have potential applications as cryoprotectants, but the relationship between structure and performance is underexplored. Here a family of zwitterions are assessed in terms of cytotoxicity, cryopreservation performance, and effect on cell volume and water content.

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

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