Журнал микробиологии, эпидемиологии и иммунобиологии (Apr 2015)

PREVALENCE OF HEPATITIS E MARKERS IN CHILDREN

  • I. A Potemkin,
  • M. A Lopatukhina,
  • O. A Gadzhieva,
  • E. L Prokhorova,
  • A. Diyarrassuba,
  • O. V Isaeva,
  • T. V Kozhanova,
  • O. E Ivanova,
  • O. V Silenova,
  • N. Kh Setdikova,
  • K. K Kyuregyan,
  • M. I Mikhailov

Journal volume & issue
Vol. 92, no. 2
pp. 38 – 46

Abstract

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Aim. Frequency of detection determination for past and current hepatitis E virus (HEV) infection markers in children with immune suppression, as well as children with normal immune status. Materials and methods. The presence of HEV markers (anti-HEV IgG and IgM, HEV RNA) was studied in 609 sera samples of children with neurologic pathologies, 87 samples - from children with immune deficiencies, as well as 3122 samples from conditionally healthy children of 6 regions of Russia. The children were divided into 5 age groups. Anti-HEV IgG and IgM determination was carried out in EIA, HEV RNA - by RT-PCR. Results. The frequency of detection of anamnestic anti-HEV IgG turned out to be significantly higher among immune-compromised children compared with healthy children (5.7% against 1.4%, p

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