Журнал микробиологии, эпидемиологии и иммунобиологии (Apr 2015)
PREVALENCE OF HEPATITIS E MARKERS IN CHILDREN
Abstract
Aim. Frequency of detection determination for past and current hepatitis E virus (HEV) infection markers in children with immune suppression, as well as children with normal immune status. Materials and methods. The presence of HEV markers (anti-HEV IgG and IgM, HEV RNA) was studied in 609 sera samples of children with neurologic pathologies, 87 samples - from children with immune deficiencies, as well as 3122 samples from conditionally healthy children of 6 regions of Russia. The children were divided into 5 age groups. Anti-HEV IgG and IgM determination was carried out in EIA, HEV RNA - by RT-PCR. Results. The frequency of detection of anamnestic anti-HEV IgG turned out to be significantly higher among immune-compromised children compared with healthy children (5.7% against 1.4%, p