Association of estrogen receptor α-351 and -397 polymorphisms with uterine leiomyoma in Chaharmahal & Bakhtiari women

Abstract

Background: Uterine leiomyoma, usually known as fibroma, is common estrogen-related a gynaecological disease and the most common disorder leading to hysterectomy. It is estimated that one in four women will develop this kind of benign neoplasia during their reproductive period, therefore, it is considered to have significant effect women’s health. This study aimed to evaluate association of estrogen receptor a (ERα)-351 A>G (XbaI) and -397 T>C (PvuII) gene polymorphisms with uterne leiomyoma in Chaharmahal & Bakhtiari’s women. Material and Methods: 156 women with clinically diagnosed uterine leiomyoma and 151 healthy, normal women were included in this case – control study. ERα-351 A/G XbaI and -397 T/C PvuII polymorphisms were assessed by the method of PCR-RFLP. Collected data were analyzed by SPSS ver.17 software, using chi square tests. Results: Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of Era -351 A>G and -397 T/C polymorphisms in leiomyoma groups were not different from those of normal controls sinificantly. Conclusion: We concluded that ERα -351 XbaI A>G and -397 PvuII T>C related genotypes/alleles were not associated with an increased risk of uterine leiomyoma in study population.

Keywords

• estrogen a receptor
• leiomyoma
• polymorphism
• estrogen