Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation

Kavitha Kankanala; Vangala Ranga Reddy; Yumnam Priyadarshini Devi; Lakshmi Narasu Mangamoori; Khagga Mukkanti; Sarbani Pal

doi:10.1155/2013/816769

Journal of Chemistry (Jan 2013)

Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation

Kavitha Kankanala,
Vangala Ranga Reddy,
Yumnam Priyadarshini Devi,
Lakshmi Narasu Mangamoori,
Khagga Mukkanti,
Sarbani Pal

Affiliations

Kavitha Kankanala: Centre for Chemical Science and Technology, IST, JNTUH, Kukatpally, Hyderabad, Andhra Pradesh 500085, India
Vangala Ranga Reddy: Dr. Reddy’s Laboratories Limited, Integrated Product Development, Bachupally, Hyderabad, Andhra Pradesh 500055, India
Yumnam Priyadarshini Devi: Centre for Biotechnology, IST, JNTUH, Kukatpally, Hyderabad, Andhra Pradesh 500085, India
Lakshmi Narasu Mangamoori: Centre for Biotechnology, IST, JNTUH, Kukatpally, Hyderabad, Andhra Pradesh 500085, India
Khagga Mukkanti: Centre for Chemical Science and Technology, IST, JNTUH, Kukatpally, Hyderabad, Andhra Pradesh 500085, India
Sarbani Pal: Department of Chemistry, MNR Degree and PG College, Kukatpally, Hyderabad, Andhra Pradesh 500085, India

DOI: https://doi.org/10.1155/2013/816769
Journal volume & issue: Vol. 2013

Abstract

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The nimesulide based novel glycolamide esters were designed and synthesized for the first time via a three-step method starting from nimesulide. Structures of the synthesized compounds were confirmed by spectroscopic analysis. All the synthesized compounds were examined for their cytotoxic effects in vitro, some of which showed significant cytotoxic activities against HCT-15 human colon cancer cell line.

Published in Journal of Chemistry

ISSN: 2090-9063 (Print); 2090-9071 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://onlinelibrary.wiley.com/journal/2962

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