PLoS ONE (Jan 2012)

Effects of dopamine on sensitivity to social bias in Parkinson's disease.

  • Atbin Djamshidian,
  • Sean S O'Sullivan,
  • Andrew Lees,
  • Bruno B Averbeck

DOI
https://doi.org/10.1371/journal.pone.0032889
Journal volume & issue
Vol. 7, no. 3
p. e32889

Abstract

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Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect.