Nature Communications (Dec 2017)
Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
- Zhengkui Zhang,
- Yao Fan,
- Feng Xie,
- Hang Zhou,
- Ke Jin,
- Li Shao,
- Wenhao Shi,
- Pengfei Fang,
- Bing Yang,
- Hans van Dam,
- Peter ten Dijke,
- Xiaofeng Zheng,
- Xiaohua Yan,
- Junling Jia,
- Min Zheng,
- Jin Jin,
- Chen Ding,
- Sheng Ye,
- Fangfang Zhou,
- Long Zhang
Affiliations
- Zhengkui Zhang
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Yao Fan
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Feng Xie
- Institutes of Biology and Medical Science, Soochow University
- Hang Zhou
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Ke Jin
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Li Shao
- State Key Laboratory for Diagnostic and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease
- Wenhao Shi
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Pengfei Fang
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Bing Yang
- Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco, San Francisco
- Hans van Dam
- Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600
- Peter ten Dijke
- Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600
- Xiaofeng Zheng
- Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center
- Xiaohua Yan
- Tsinghua University
- Junling Jia
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Min Zheng
- State Key Laboratory for Diagnostic and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease
- Jin Jin
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Chen Ding
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Sheng Ye
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- Fangfang Zhou
- Institutes of Biology and Medical Science, Soochow University
- Long Zhang
- Life Sciences Institute and Innovation Center for Cell Signalling Network, Zhejiang University
- DOI
- https://doi.org/10.1038/s41467-017-02029-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
The activation of TGF-β signaling has been implicated in cancer metastasis. Here, the authors show that OTUD1 suppresses metastasis by antagonizing the TGF-β pathway via the deubiquitination of SMAD7, and its loss correlates with poor prognosis in breast cancer.
