Nature Communications (Feb 2019)

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

  • David M. Gay,
  • Rachel A. Ridgway,
  • Miryam Müller,
  • Michael C. Hodder,
  • Ann Hedley,
  • William Clark,
  • Joshua D. Leach,
  • Rene Jackstadt,
  • Colin Nixon,
  • David J. Huels,
  • Andrew D. Campbell,
  • Thomas G. Bird,
  • Owen J. Sansom

DOI
https://doi.org/10.1038/s41467-019-08586-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.