DNA methylation repels targeting of Arabidopsis REF6

Qi Qiu; Hailiang Mei; Xian Deng; Kaixuan He; Baixing Wu; Qingqing Yao; Jixiang Zhang; Falong Lu; Jinbiao Ma; Xiaofeng Cao

doi:10.1038/s41467-019-10026-1

Nature Communications (May 2019)

DNA methylation repels targeting of Arabidopsis REF6

Qi Qiu,
Hailiang Mei,
Xian Deng,
Kaixuan He,
Baixing Wu,
Qingqing Yao,
Jixiang Zhang,
Falong Lu,
Jinbiao Ma,
Xiaofeng Cao

Affiliations

Qi Qiu: State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Hailiang Mei: State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Xian Deng: State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Kaixuan He: State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Baixing Wu: State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Qingqing Yao: State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Jixiang Zhang: University of Chinese Academy of Sciences
Falong Lu: University of Chinese Academy of Sciences
Jinbiao Ma: State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Xiaofeng Cao: State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-10026-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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REF6 is a H3K27me3 histone demethylase that targets regions of active chromatin in the Arabidopsis genome. Here Qiu et al. show that REF6 preferentially binds unmethylated DNA via its zinc-finger domains suggesting that DNA methylation might deter REF6 binding in heterochromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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