Beilstein Journal of Organic Chemistry (Sep 2024)

Hypervalent iodine-mediated cyclization of bishomoallylamides to prolinols

  • Smaher E. Butt,
  • Konrad Kepski,
  • Jean-Marc Sotiropoulos,
  • Wesley J. Moran

DOI
https://doi.org/10.3762/bjoc.20.209
Journal volume & issue
Vol. 20, no. 1
pp. 2455 – 2460

Abstract

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A change in mechanism was observed in the hypervalent iodine-mediated cyclization of N-alkenylamides when the carbon chain between the alkene and the amide increased from two to three atoms. In the latter case, cyclization at the amide nitrogen to form the pyrrolidine ring was favored over cyclization at the amide oxygen. A DFT study was undertaken to rationalize the change in mechanism of this cyclization process. In addition, reaction conditions were developed, and the scope of this cyclization studied.

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