Acta Crystallographica Section E (May 2009)

(1R,3S,5R,6S)-6-Acetoxy-8-methyl-3-(p-tolylsulfonyloxy)-8-azoniabicyclo[3.2.1]octane (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate

  • Yang Lu,
  • Hong-Zhuan Chen,
  • Ya-Fang Gu,
  • Yi-Fan Xie,
  • Li-Min Yang

DOI
https://doi.org/10.1107/S1600536809012732
Journal volume & issue
Vol. 65, no. 5
pp. o1037 – o1037

Abstract

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The title compound, C17H24NO5S+·C18H13O8−, is the key intermediate during the preparation of lesatropane [systematic name (1R,3S,5R,6S)-6-acetoxy-3-(4-methylphenylsulfonyloxy)tropane], a potential antiglaucoma agent. The tertiary N atom of the tropane ring is involved in intermolecular N—H...O hydrogen bonding, and the carboxylate groups are involved in intermolecular O—H...O hydrogen bonding.