Influenza B Viruses with Mutation in the Neuraminidase Active Site, North Carolina, USA, 2010–11

Abstract

Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.

Keywords

• zanamivir
• oseltamivir
• peramivir
• neuraminidase inhibitor
• viruses
• North Carolina