Vitamin D and vitamin D receptor levels in children with attention-deficit/hyperactivity disorder

Abstract

Nilfer Sahin,1 Hatice Altun,2 Ergül Belge Kurutas,3 Damla Balkan1 1Department of Child and Adolescent Psychiatry, Muğla Sıtkı Koçman University, Muğla, Turkey; 2Department of Child and Adolescent Psychiatry, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey; 3Department of Biochemistry, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey Objective: In this study, we aimed to evaluate vitamin D and vitamin D receptor levels in children with attention-deficit/hyperactivity disorder (ADHD). Patients and methods: In this cross-sectional study, a total of 80 children including 40 ADHD patients (aged 6–12 years; 28 males and 12 females) and 40 age-, sex-, and season of blood collection-matched controls (aged 6–12 years; 25 males and 15 females) were enrolled. Serum vitamin D and vitamin D receptor levels and calcium, phosphorus, and alkaline phosphatase were measured. The vitamin D receptor levels in the serum were measured using the quantitative sandwich enzyme immunoassay technique. Results: Serum vitamin D and vitamin D receptor levels were found to be significantly lower in children with ADHD compared to healthy controls. No significant differences were found in serum calcium, phosphorus, and alkaline phosphatase levels. No significant differences were found among the ADHD subtypes in terms of serum vitamin D, vitamin D receptor, calcium, phosphorus and alkaline phosphatase levels. Conclusion: This study suggests that children with ADHD have lower levels of vitamin D and vitamin D receptor. According to the authors’ knowledge, this is the first study to describe vitamin D receptor levels in ADHD. Keywords: attention-deficit/hyperactivity disorder, vitamin D, vitamin D receptor

Keywords

• attention deficit hyperactivity disorder
• vitamin D
• vitamin D receptor