Disposable Pencil Graphite Electrode for Diosmin Voltammetric Analysis
Iulia Gabriela David,
Alexandra-Gabriela Oancea,
Mihaela Buleandră,
Dana Elena Popa,
Emilia Elena Iorgulescu,
Adela Magdalena Ciobanu
Affiliations
Iulia Gabriela David
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Alexandra-Gabriela Oancea
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Mihaela Buleandră
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Dana Elena Popa
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Emilia Elena Iorgulescu
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Adela Magdalena Ciobanu
Discipline of Psychiatry, Neurosciences Department, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Dionisie Lupu Street 37, 020021 Bucharest, Romania
Diosmin (DIO) is a naturally occurring flavonoid with multiple beneficial effects on human health. The presence of different hydroxyl groups in diosmin structure enables its electrochemical investigation and quantification. This work presents, for the first time, diosmin voltammetric behavior and quantification on the cost-effective, disposable pencil graphite electrode (PGE). Diosmin oxidation on PGE involves two irreversible steps, generating products with reversible redox behaviors. All electrode processes are pH-dependent and predominantly adsorption-controlled. Differential pulse (DPV) and adsorptive stripping differential pulse (AdSDPV) voltammetric methods have been optimized for diosmin quantification o an H-type PGE, in 0.100 mol/L H2SO4. The linear ranges and limits of detection were for DPV 1.00 × 10−6–1.00 × 10−5 mol/L and 2.76 × 10−7 mol/L DIO for DPV and 1.00 × 10−7–2.50 × 10−6 mol/L and 7.42 × 10−8 mol/L DIO for AdSDPV, respectively. The DPV method was successfully applied for diosmin quantification in dietary supplement tablets. The percentage recovery was 99.87 ± 4.88%.
