Dynamics of metabolic parameters partial vascular isolation of liver in rats

Abstract

This article presents the results of dynamic changes in biochemical parameters in blood and liver of laboratory animals in modeling of partial vascular isolation of liver using a Pringle-maneuver. Indicators of cytolytic syndrome, prooxidantantioxidant and detoxification system function was studied. Research found evidence of a gradual increase of cytolysis of hepatocytes, intensity of free radical processes, endogenous intoxication, which accompanied of compensatory systems activation by the first 10-15 minutes, and being depleted to 20 minutes of ischemia. These data reveal prospects of metabolic correction of possible complications intraoperative clamping hepatoduodenal bunch by means of antioxidant orientation. Received data may be useful in the formation of concepts about the reasonable time limits of liver vascular isolation.

Keywords

• сосудистая изоляция печени
• цитолиз гепатоцитов
• антиоксидантная система
• окислительный стресс
• эндогенная интоксикация
• liver vascular isolation
• cytolysis of hepatocytes
• antioxidant system
• oxidative stress
• endogenous intoxication