Accelerated Skin Wound Healing Using Flexible Photovoltaic-Bioelectrode Electrical Stimulation
Chao Han,
Junfei Huang,
Aodi Zhangji,
Xufeng Tong,
Kaige Yu,
Kai Chen,
Xinlan Liu,
Yang Yang,
Yuxin Chen,
Waqar Ali Memon,
Kamran Amin,
Wanlei Gao,
Zexing Deng,
Kun Zhou,
Yuheng Wang,
Xiangdong Qi
Affiliations
Chao Han
Department of Plastic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China
Junfei Huang
Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China
Aodi Zhangji
Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China
Xufeng Tong
The Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315211, China
Kaige Yu
The Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315211, China
Kai Chen
The Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315211, China
Xinlan Liu
Medical College, Ningbo University, Ningbo 315000, China
Yang Yang
Department of Plastic and Reconstructive Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Yuxin Chen
The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
Waqar Ali Memon
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Kamran Amin
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Wanlei Gao
The Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315211, China
Zexing Deng
College of Materials Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China
Kun Zhou
School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China
Yuheng Wang
The Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315211, China
Xiangdong Qi
Department of Plastic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China
Owing to the complex and long-term treatment of foot wounds due to diabetes and the limited mobility of patients, advanced clinical surgery often uses wearable flexible devices for auxiliary treatment. Therefore, there is an urgent need for self-powered biomedical devices to reduce the extra weight. We have prepared an electrically stimulated MEMS (Micro Electromechanical System) electrode integrated with wearable OPV (Organic photovoltaic). The wearable OPV is constructed of a bio-affinity PET-ITO substrate and a hundred-nanometer organic layer. Under sunlight and near-infrared light irradiation, a voltage and current are supplied to the MEMS electrode to generate an exogenous lateral electric field directed to the center of the wound. The results of in vitro cell experiments and diabetic skin-relieving biological experiments showed the proliferation of skin fibroblasts and the expression of transforming growth factors increased, and the skin wounds of diabetic mouse healed faster. Our research provides new insights for the clinical treatment of diabetes.
