Nature Communications (Sep 2019)

Massive computational acceleration by using neural networks to emulate mechanism-based biological models

  • Shangying Wang,
  • Kai Fan,
  • Nan Luo,
  • Yangxiaolu Cao,
  • Feilun Wu,
  • Carolyn Zhang,
  • Katherine A. Heller,
  • Lingchong You

DOI
https://doi.org/10.1038/s41467-019-12342-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Mechanistic models provide valuable insights, but large-scale simulations are computationally expensive. Here, the authors show that it is possible to explore the dynamics of a mechanistic model over a large set of parameters by training an artificial neural network on a smaller set of simulations.