Choroid plexus epithelium and its role in neurological diseases

Ruizhen Liu; Ruizhen Liu; Ruizhen Liu; Zhiping Zhang; Zhiping Zhang; Zhiping Zhang; Yibing Chen; Yibing Chen; Yibing Chen; Junbo Liao; Junbo Liao; Junbo Liao; Yuchang Wang; Yuchang Wang; Yuchang Wang; Jingping Liu; Jingping Liu; Jingping Liu; Zhixiong Lin; Gelei Xiao; Gelei Xiao; Gelei Xiao

doi:10.3389/fnmol.2022.949231

Frontiers in Molecular Neuroscience (Oct 2022)

Choroid plexus epithelium and its role in neurological diseases

Ruizhen Liu,
Ruizhen Liu,
Ruizhen Liu,
Zhiping Zhang,
Zhiping Zhang,
Zhiping Zhang,
Yibing Chen,
Yibing Chen,
Yibing Chen,
Junbo Liao,
Junbo Liao,
Junbo Liao,
Yuchang Wang,
Yuchang Wang,
Yuchang Wang,
Jingping Liu,
Jingping Liu,
Jingping Liu,
Zhixiong Lin,
Gelei Xiao,
Gelei Xiao,
Gelei Xiao

Affiliations

Ruizhen Liu: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Ruizhen Liu: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Ruizhen Liu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Zhiping Zhang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Zhiping Zhang: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Zhiping Zhang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yibing Chen: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Yibing Chen: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Yibing Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Junbo Liao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Junbo Liao: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Junbo Liao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yuchang Wang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Yuchang Wang: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Yuchang Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Jingping Liu: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Jingping Liu: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Jingping Liu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Zhixiong Lin: Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China
Gelei Xiao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Gelei Xiao: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Gelei Xiao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fnmol.2022.949231
Journal volume & issue: Vol. 15

Abstract

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Choroid plexus epithelial cells can secrete cerebrospinal fluid into the ventricles, serving as the major structural basis of the selective barrier between the neurological system and blood in the brain. In fact, choroid plexus epithelial cells release the majority of cerebrospinal fluid, which is connected with particular ion channels in choroid plexus epithelial cells. Choroid plexus epithelial cells also produce and secrete a number of essential growth factors and peptides that help the injured cerebrovascular system heal. The pathophysiology of major neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, as well as minor brain damage diseases like hydrocephalus and stroke is still unknown. Few studies have previously connected choroid plexus epithelial cells to the etiology of these serious brain disorders. Therefore, in the hopes of discovering novel treatment options for linked conditions, this review extensively analyzes the association between choroid plexus epithelial cells and the etiology of neurological diseases such as Alzheimer's disease and hydrocephalus. Finally, we review CPE based immunotherapy, choroid plexus cauterization, choroid plexus transplantation, and gene therapy.

Published in Frontiers in Molecular Neuroscience

ISSN: 1662-5099 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/molecular-neuroscience

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