Molecular & Cellular Oncology (Sep 2018)
Dual mechanism of DICER downregulation facilitates cancer metastasis
Abstract
Although downregulation of DICER – a critical enzyme in microRNA (miRNA) maturation – reportedly promotes cancer metastasis, understanding of its upstream regulators remains limited. Our recent study demonstrated a noncanonical oncogenic effect of hypoxia-inducible factor-1α (HIF-1α), which directly binds with DICER to promote PARKIN-mediated autophagic–lysosomal proteolysis and consequently suppresses miRNA biogenesis, facilitating metastasis.
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