Nature Communications (Sep 2017)
A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis
- Jing-Rong Wang,
- Wei-Na Gao,
- Rudolf Grimm,
- Shibo Jiang,
- Yong Liang,
- Hua Ye,
- Zhan-Guo Li,
- Lee-Fong Yau,
- Hao Huang,
- Ju Liu,
- Min Jiang,
- Qiong Meng,
- Tian-Tian Tong,
- Hai-Hui Huang,
- Stephanie Lee,
- Xing Zeng,
- Liang Liu,
- Zhi-Hong Jiang
Affiliations
- Jing-Rong Wang
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Wei-Na Gao
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Rudolf Grimm
- Agilent Technologies
- Shibo Jiang
- Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Basic Medical College, Fudan University
- Yong Liang
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Hua Ye
- Department of Rheumatology and Immunology, Peking University People’s Hospital
- Zhan-Guo Li
- Department of Rheumatology and Immunology, Peking University People’s Hospital
- Lee-Fong Yau
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Hao Huang
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Ju Liu
- Division of Rheumatology, Jiujiang First People’s Hospital
- Min Jiang
- Division of Rheumatology, Jiujiang First People’s Hospital
- Qiong Meng
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Tian-Tian Tong
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Hai-Hui Huang
- Faculty of Information Technology, Macau University of Science and Technology
- Stephanie Lee
- Agilent Technologies Hong Kong Ltd.
- Xing Zeng
- Guangdong Provincial Hospital of Chinese Medicine
- Liang Liu
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Zhi-Hong Jiang
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-017-00662-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Post-translational modifications can affect antibody function in health and disease, but identification of all variants is difficult using existing technologies. Here the authors develop a microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs can be used as biomarkers for rheumatoid arthritis.
