Communications Biology (Jan 2021)

Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction

  • Dasol Kim,
  • Hui-Yun Hwang,
  • Eun Sun Ji,
  • Jin Young Kim,
  • Jong Shin Yoo,
  • Ho Jeong Kwon

DOI
https://doi.org/10.1038/s42003-020-01566-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 17

Abstract

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Kim, Hwang et al. use in vitro and in vivo models of autophagy disorder/metabolic dysfunction to show that in this context, the natural compound kaempferide is an autophagy enhancer and reveal that one of the underlying mechanisms governing this is mediated by the mitochondrial elongation factor TUFM. This insight may have therapeutic value in the treatment of metabolic disorders.