Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Inah Hwang; Hiroki Uchida; Ziwei Dai; Fei Li; Teresa Sanchez; Jason W. Locasale; Lewis C. Cantley; Hongwu Zheng; Jihye Paik

doi:10.1038/s41467-020-20839-0

Nature Communications (Jan 2021)

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Inah Hwang,
Hiroki Uchida,
Ziwei Dai,
Fei Li,
Teresa Sanchez,
Jason W. Locasale,
Lewis C. Cantley,
Hongwu Zheng,
Jihye Paik

Affiliations

Inah Hwang: Department of Pathology and Laboratory medicine, Weil Cornell Medicine
Hiroki Uchida: Department of Pathology and Laboratory medicine, Weil Cornell Medicine
Ziwei Dai: Department of Pharmacology and Cancer Biology, Duke University School of Medicine
Fei Li: Department of Neurosurgery, Southwest Hospital
Teresa Sanchez: Department of Pathology and Laboratory medicine, Weil Cornell Medicine
Jason W. Locasale: Department of Pharmacology and Cancer Biology, Duke University School of Medicine
Lewis C. Cantley: Department of Medicine, Weil Cornell Medicine
Hongwu Zheng: Department of Pathology and Laboratory medicine, Weil Cornell Medicine
Jihye Paik: Department of Pathology and Laboratory medicine, Weil Cornell Medicine

DOI: https://doi.org/10.1038/s41467-020-20839-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-cGAS/STING-IFN-I signalling cascade initiated by FOXO3 oxidation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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