Nature Communications (Jun 2017)
Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment
Abstract
Features of major depressive disorder including lack of motivation, sleep disruption and cognitive deficit have been modelled in rodents. Here, the authors develop a new method to elicit a depression-like state inDrosophila, and uncover separable roles for different serotonin receptors in depression-like behaviour.