Nature Communications (Jun 2017)

Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment

  • Ariane-Saskia Ries,
  • Tim Hermanns,
  • Burkhard Poeck,
  • Roland Strauss

DOI
https://doi.org/10.1038/ncomms15738
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Features of major depressive disorder including lack of motivation, sleep disruption and cognitive deficit have been modelled in rodents. Here, the authors develop a new method to elicit a depression-like state inDrosophila, and uncover separable roles for different serotonin receptors in depression-like behaviour.