Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): Proof of concept in the human

David Escobar Sanabria; Joshua E. Aman; Valentina Zapata Amaya; Luke A. Johnson; Hafsa Farooqi; Jing Wang; Meghan Hill; Remi Patriat; Kelly Sovell-Brown; Gregory F. Molnar; David Darrow; Robert McGovern; Scott E. Cooper; Noam Harel; Colum D. MacKinnon; Michael C. Park; Jerrold L. Vitek

Brain Stimulation (Sep 2022)

Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): Proof of concept in the human

David Escobar Sanabria,
Joshua E. Aman,
Valentina Zapata Amaya,
Luke A. Johnson,
Hafsa Farooqi,
Jing Wang,
Meghan Hill,
Remi Patriat,
Kelly Sovell-Brown,
Gregory F. Molnar,
David Darrow,
Robert McGovern,
Scott E. Cooper,
Noam Harel,
Colum D. MacKinnon,
Michael C. Park,
Jerrold L. Vitek

Affiliations

David Escobar Sanabria: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA; Corresponding author.
Joshua E. Aman: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Valentina Zapata Amaya: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Luke A. Johnson: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Hafsa Farooqi: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Jing Wang: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Meghan Hill: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Remi Patriat: Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, USA
Kelly Sovell-Brown: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Gregory F. Molnar: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
David Darrow: Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA
Robert McGovern: Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA
Scott E. Cooper: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Noam Harel: Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, USA
Colum D. MacKinnon: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA
Michael C. Park: Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA
Jerrold L. Vitek: Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA; Corresponding author.

Journal volume & issue: Vol. 15, no. 5
pp. 1111 – 1119

Abstract

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Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 13–35 Hz (“beta band”) oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical pulses with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16–22 Hz) neural activity in a PD patient. Our results highlight the utility of eiDBS to characterize the role of oscillatory dynamics in PD and other brain conditions, and to develop personalized neuromodulation systems.

Published in Brain Stimulation

ISSN: 1935-861X (Print); 1876-4754 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-stimulation

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