Enzyme-catalyzed allylic oxidation reactions: A mini-review

Maoyao Wang; Maoyao Wang; Xiaojian Zhou; Xiaojian Zhou; Zhongqiang Wang; Zhongqiang Wang; Yongzheng Chen; Yongzheng Chen

doi:10.3389/fchem.2022.950149

Frontiers in Chemistry (Aug 2022)

Enzyme-catalyzed allylic oxidation reactions: A mini-review

Maoyao Wang,
Maoyao Wang,
Xiaojian Zhou,
Xiaojian Zhou,
Zhongqiang Wang,
Zhongqiang Wang,
Yongzheng Chen,
Yongzheng Chen

Affiliations

Maoyao Wang: Key Laboratory of Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi Medical University, Zunyi, China
Maoyao Wang: Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China
Xiaojian Zhou: Key Laboratory of Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi Medical University, Zunyi, China
Xiaojian Zhou: Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China
Zhongqiang Wang: Key Laboratory of Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi Medical University, Zunyi, China
Zhongqiang Wang: Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China
Yongzheng Chen: Key Laboratory of Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi Medical University, Zunyi, China
Yongzheng Chen: Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China

DOI: https://doi.org/10.3389/fchem.2022.950149
Journal volume & issue: Vol. 10

Abstract

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Chiral allylic oxidized products play an increasingly important role in the pharmaceutical, agrochemical, and pharmaceutical industries. Biocatalytic C–H oxyfunctionalization to synthesize allylic oxidized products has attracted great attention in recent years, with the ability to simplify synthetic approaches toward complex compounds. As a result, scientists have found some new enzymes and mutants through techniques of gene mining and enzyme-directed evolution in recent years. This review summarizes the recent developments in biocatalytic selective oxidation of olefins by different kinds of biocatalysts.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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