Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
Jing Lao,
Xin-Ping Song,
Huan-Sheng Wang,
Ren-Sen Jiang,
Yu Luo,
Jun Sun,
Zhi-Han Li,
Chi Li,
Ji-Kui Deng,
Bin Wang,
Xiao-Peng Ma,
Jian-Yao Wang
Affiliations
Jing Lao
Shenzhen Children's Hospital of China Medical University, Shenzhen 518026, Guangdong Province, China
Xin-Ping Song
Shenzhen Children's Hospital of China Medical University, Shenzhen 518026, Guangdong Province, China
Huan-Sheng Wang
Shenzhen Children's Hospital of China Medical University, Shenzhen 518026, Guangdong Province, China
Ren-Sen Jiang
Shenzhen Children's Hospital of China Medical University, Shenzhen 518026, Guangdong Province, China; Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China; Department of Infection, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China; Shenzhen Children's Hospital of Shantou University, Shenzhen 518026, Guangdong Province, China
Yu Luo
Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China
Jun Sun
Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China
Zhi-Han Li
Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China
Chi Li
Department of Infection, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China
Ji-Kui Deng
Department of Infection, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China
Bin Wang
Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China
Xiao-Peng Ma
Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China
Jian-Yao Wang
Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China; Corresponding author.
Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed ''solid'' liver abscess. After undergoing surgical anatomical hepatic lobectomy, the child's infection symptoms showed improvement. The postoperative culture of the purulent material from the liver infection lesion revealed an infection with Staphylococcus aureus. Our case raises the possibility of pathogen sources and routes of infection, clinical characteristics, and effective treatment for SCN patients with concomitant liver abscess.