Open eyes and closed eyes elicit different temporal properties of brain functional networks
Yihe Weng,
Xiaojin Liu,
Huiqing Hu,
Huiyuan Huang,
Senning Zheng,
Qinyuan Chen,
Jie Song,
Bolin Cao,
Junjing Wang,
Shuai Wang,
Ruiwang Huang
Affiliations
Yihe Weng
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Xiaojin Liu
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Huiqing Hu
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Huiyuan Huang
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Senning Zheng
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Qinyuan Chen
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Jie Song
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Bolin Cao
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Junjing Wang
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Shuai Wang
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China
Ruiwang Huang
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, 510631 Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, 510631 Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China; Corresponding author at: School of Psychology, South China Normal University, Guangzhou 510631, China.
The eyes are our windows to the brain. There are differences in brain activity between people who have their eyes closed (EC) and eyes open (EO). Previous studies focused on differences in brain functional properties between these eyes conditions based on an assumption that brain activity is a static phenomenon. However, the dynamic nature of the brain activity in different eyes conditions is still unclear. In this study, we collected resting-state fMRI data from 21 healthy subjects in the EC and EO conditions. Using a sliding time window approach and a k-means clustering algorithm, we calculated the temporal properties of dynamic functional connectivity (dFC) states in the eyes conditions. We also used graph theory to estimate the dynamic topological properties of functional networks in the two conditions. We detected two dFC states, a hyper-connected State 1 and a hypo-connected State 2. We showed the following results: (i) subjects in the EC condition stayed longer in the hyper-connected State 1 than those in the EO; (ii) subjects in the EO condition stayed longer in the hypo-connected State 2 than those in the EC; and (iii) the dFC state transformed into the other state more frequently during EC than during EO. We also found the variance of the characteristic path length was higher during EC than during EO in the hyper-connected State 1. These results indicate that brain activity may be more active and unstable during EC than during EO. Our findings may provide insights into the dynamic nature of the resting-state brain and could be a useful reference for future rs-fMRI studies.
