Prevention of venous thromboembolic events in ischemic stroke

Abstract

The prevention of venous thromboembolic events (VTEEs) combining leg vein thrombosis and pulmonary thromboembolism is one of the effective areas in the management of patients with ischemic stroke. Methods for prevention of VTEEs and their risk factors in this disease are analyzed. The prevention of VTEEs involves maximally early activation of a patient with stroke, adequate fluid administration into the body, and therapeutic gymnastics. The use of unfractionated heparin (UFH) and low-molecular-weight heparins (LMWH) is effective as medications. The results of trials comparing the efficacy of UFH and LMWH in ischemic stroke are presented. Enoxaparin is noted to be superior to UFH in preventing VTEEs. The economic calculations show that the use of LMWH instead of UFH may lead to a reduction in the total cost of treatment for ischemic stroke due to the lower expenditures on therapy for VTEEs.

Keywords

• leg vein thrombosis
• pulmonary thromboembolism
• venous thromboembolic events
• ischemic stroke
• unfractionated heparin
• low-molecular-weight heparins
• enoxaparin