Neutrophil/Lymphocyte Ratio as Predictor of Anastomotic Leak after Gastric Cancer Surgery
Dumitru Radulescu,
Vlad Dumitru Baleanu,
Vlad Padureanu,
Patricia Mihaela Radulescu,
Silviu Bordu,
Stefan Patrascu,
Bogdan Socea,
Nicolae Bacalbasa,
Marin Valeriu Surlin,
Ion Georgescu,
Eugen Florin Georgescu
Affiliations
Dumitru Radulescu
General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Vlad Dumitru Baleanu
General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Vlad Padureanu
Internal Medicine Department, County Hospital of Craiova, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Patricia Mihaela Radulescu
“Victor Babes” Clinical Hospital of Infectious Diseases and Pneumophtisiology Craiova, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Silviu Bordu
General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Stefan Patrascu
General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Bogdan Socea
General Surgery Department, “Carol Davila” University of Medicine and Pharmacy, 021659 Bucharest, Romania
Nicolae Bacalbasa
“Dr. Ion Cantacuzino” Hospital, Gynecology Department, “Carol Davila” University of Medicine and Pharmacy, 020457 Bucharest, Romania
Marin Valeriu Surlin
General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Ion Georgescu
General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Eugen Florin Georgescu
General Surgery Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Introduction. Neutrophil/lymphocyte ratio (NLR) is known as a prognostic for the outcome of the patients with gastric cancer. As no definite risk marker for anastomotic leakage after gastric resection was identified, we investigated the possible role of NLR. Methods. Peripheral blood count for neutrophils and lymphocytes was done at the patient’s admission. We retrospectively evaluated 204 gastric cancer patients, who underwent gastric resection, comparing the values of NLR between the group of patients with anastomotic leakage and those without complications. Results. Using the ROC curve, we found the cutoff value of NLR, which permitted the comparison of the group with low NLR, presenting increased NLR. The cutoff value for NLR was 3.54. Between the two groups, we could observe statistically significant differences in developing fistula (p p < 0.025). The odds ratio for patients with NLR greater than 3.54 to develop anastomotic leak was 17.62, compared to those with lower NLR. Conclusion. Peripheral blood NLR proved to be a predictor for anastomotic leakage.
