Behavioral Sciences (Dec 2016)

Peripheral Inflammatory Markers Contributing to Comorbidities in Autism

  • Martha Cecilia Inga Jácome,
  • Lilia Maria Morales Chacòn,
  • Hector Vera Cuesta,
  • Carlos Maragoto Rizo,
  • Mabel Whilby Santiesteban,
  • Lesyanis Ramos Hernandez,
  • Elena Noris García,
  • Maria Elena González Fraguela,
  • Caridad Ivette Fernandez Verdecia,
  • Yamilé Vegas Hurtado,
  • Dario Siniscalco,
  • Carlos Alberto Gonçalves,
  • Maria de los Angeles Robinson-Agramonte

Journal volume & issue
Vol. 6, no. 4
p. 29


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This study evaluates the contribution of peripheral biomarkers to comorbidities and clinical findings in autism. Seventeen autistic children and age-matched typically developing (AMTD), between three to nine years old were evaluated. The diagnostic followed the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DMS-IV) and the Childhood Autism Rating Scale (CARS) was applied to classify the severity. Cytokine profile was evaluated in plasma using a sandwich type ELISA. Paraclinical events included electroencephalography (EEG) record. Statistical analysis was done to explore significant differences in cytokine profile between autism and AMTD groups and respect clinical and paraclinical parameters. Significant differences were found to IL-1β, IL-6, IL-17, IL-12p40, and IL-12p70 cytokines in individuals with autism compared with AMTD (p < 0.05). All autistic patients showed interictalepileptiform activity at EEG, however, only 37.5% suffered epilepsy. There was not a regional focalization of the abnormalities that were detectable with EEG in autistic patients with history of epilepsy. A higher IL-6 level was observed in patients without history of epilepsy with interictalepileptiform activity in the frontal brain region, p < 0.05. In conclusion, peripheral inflammatory markers might be useful as potential biomarkers to predict comorbidities in autism as well as reinforce and aid informed decision-making related to EEG findings in children with Autism spectrum disorders (ASD).