Frontiers in Ecology and Evolution (May 2022)
Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution
- Antoine M. Dujon,
- Antoine M. Dujon,
- Justine Boutry,
- Sophie Tissot,
- Jean-François Lemaître,
- Amy M. Boddy,
- Anne-Lise Gérard,
- Anne-Lise Gérard,
- Alexandra Alvergne,
- Audrey Arnal,
- Orsolya Vincze,
- Orsolya Vincze,
- Delphine Nicolas,
- Mathieu Giraudeau,
- Marina Telonis-Scott,
- Aaron Schultz,
- Pascal Pujol,
- Peter A. Biro,
- Christa Beckmann,
- Christa Beckmann,
- Christa Beckmann,
- Rodrigo Hamede,
- Benjamin Roche,
- Benjamin Roche,
- Beata Ujvari,
- Frédéric Thomas
Affiliations
- Antoine M. Dujon
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- Antoine M. Dujon
- Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
- Justine Boutry
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- Sophie Tissot
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- Jean-François Lemaître
- CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Université de Lyon, Université Lyon 1, Villeurbanne, France
- Amy M. Boddy
- Department of Anthropology, University of California, Santa Barbara, Santa Barbara, CA, United States
- Anne-Lise Gérard
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- Anne-Lise Gérard
- Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
- Alexandra Alvergne
- Institut des Sciences de l’Evolution de Montpellier, Université de Montpellier, Montpellier, France
- Audrey Arnal
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- Orsolya Vincze
- Institute of Aquatic Ecology, Centre for Ecological Research, Debrecen, Hungary
- Orsolya Vincze
- Evolutionary Ecology Group, Hungarian Department of Biology and Ecology, Babes-Bolyai University, Cluj-Napoca, Romania
- Delphine Nicolas
- Tour du Valat, Institut de Recherche Pour la Conservation des Zones Humides Méditerranéennes, Arles, France
- Mathieu Giraudeau
- LIENSs,UMR 7266 CNRS-La Rochelle Université, La Rochelle, France
- Marina Telonis-Scott
- Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
- Aaron Schultz
- Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
- Pascal Pujol
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- Peter A. Biro
- Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
- Christa Beckmann
- Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
- Christa Beckmann
- 0School of Science, Western Sydney University, Penrith, NSW, Australia
- Christa Beckmann
- 1Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW, Australia
- Rodrigo Hamede
- 2School of Natural Sciences, University of Tasmania, Hobart, TAS, Australia
- Benjamin Roche
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- Benjamin Roche
- 3Fauna Silvestre y Animales de Laboratorio, Departamento de Etología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City, Mexico
- Beata Ujvari
- Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC, Australia
- Frédéric Thomas
- Unité Mixte de Recherches, CREEC/CANECEV (CREES), MIVEGEC, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
- DOI
- https://doi.org/10.3389/fevo.2022.861103
- Journal volume & issue
-
Vol. 10
Abstract
Reproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research.
Keywords
