Efficient O-deallylation triggered by cobalt hydride-catalyzed oxidative hydrofunctionalization

Yun-Nian Yin; Han-Yuan Liu; Dong-Chen Ouyang; Qing Zhang; Rong Zhu

Green Synthesis and Catalysis (Feb 2023)

Efficient O-deallylation triggered by cobalt hydride-catalyzed oxidative hydrofunctionalization

Yun-Nian Yin,
Han-Yuan Liu,
Dong-Chen Ouyang,
Qing Zhang,
Rong Zhu

Affiliations

Yun-Nian Yin: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Han-Yuan Liu: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Dong-Chen Ouyang: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Qing Zhang: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Rong Zhu: Corresponding author.; Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Journal volume & issue: Vol. 4, no. 1
pp. 64 – 66

Abstract

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Allyl protection is widely used in organic synthesis. Herein, we describe an efficient and general protocol for O-deallylation via cobalt hydride-catalyzed oxidative hydrofunctionalization. Using a green oxidant, namely oxone, this method smoothly delivers allyl deprotection products, including 1°/2°/3° alcohols, phenols and carboxylic acids.

Published in Green Synthesis and Catalysis

ISSN: 2666-5549 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/green-synthesis-and-catalysis/

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