Nature Communications (Mar 2022)

The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross

  • Takeshi Matsui,
  • Martin N. Mullis,
  • Kevin R. Roy,
  • Joseph J. Hale,
  • Rachel Schell,
  • Sasha F. Levy,
  • Ian M. Ehrenreich

DOI
https://doi.org/10.1038/s41467-022-29111-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Heritable traits can be affected by additive, dominance, and epistatic effects at genetic loci. Here, the authors use chromosomally-encoded barcodes to perform linkage mapping in diploid cross progeny in budding yeast, finding that epistasis in diploids frequently modifies both additivity and dominance.