Nature Communications (Mar 2022)
The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross
Abstract
Heritable traits can be affected by additive, dominance, and epistatic effects at genetic loci. Here, the authors use chromosomally-encoded barcodes to perform linkage mapping in diploid cross progeny in budding yeast, finding that epistasis in diploids frequently modifies both additivity and dominance.