Nature Communications (Nov 2022)
Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death
- Michal Scur,
- Ahmad Bakur Mahmoud,
- Sayanti Dey,
- Farah Abdalbarri,
- Iona Stylianides,
- Daniel Medina-Luna,
- Gayani S. Gamage,
- Aaron Woblistin,
- Alexa N. M. Wilson,
- Haggag S. Zein,
- Ashley Stueck,
- Andrew Wight,
- Oscar A. Aguilar,
- Francesca Di Cara,
- Brendon D. Parsons,
- Mir Munir A. Rahim,
- James R. Carlyle,
- Andrew P. Makrigiannis
Affiliations
- Michal Scur
- Department of Microbiology and Immunology, Dalhousie University
- Ahmad Bakur Mahmoud
- College of Applied Medical Science, Taibah University
- Sayanti Dey
- Department of Microbiology and Immunology, Dalhousie University
- Farah Abdalbarri
- Department of Pathology, McGill University
- Iona Stylianides
- Department of Microbiology and Immunology, Dalhousie University
- Daniel Medina-Luna
- Department of Microbiology and Immunology, Dalhousie University
- Gayani S. Gamage
- Department of Microbiology and Immunology, Dalhousie University
- Aaron Woblistin
- Department of Biochemistry, Dalhousie University
- Alexa N. M. Wilson
- Department of Microbiology and Immunology, Dalhousie University
- Haggag S. Zein
- Department of Microbiology and Immunology, Dalhousie University
- Ashley Stueck
- Department of Pathology, Dalhousie University
- Andrew Wight
- Department of Immunology, Dana-Farber Cancer Institute
- Oscar A. Aguilar
- Department of Microbiology and Immunology, University of California
- Francesca Di Cara
- Department of Microbiology and Immunology, Dalhousie University
- Brendon D. Parsons
- Department of Microbiology and Immunology, Dalhousie University
- Mir Munir A. Rahim
- Department of Biomedical Sciences, University of Windsor
- James R. Carlyle
- Department of Immunology, University of Toronto
- Andrew P. Makrigiannis
- Department of Microbiology and Immunology, Dalhousie University
- DOI
- https://doi.org/10.1038/s41467-022-34935-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Alveolar macrophages (AM) in the lungs maintain surfactant during homeostasis and respond to infectious pathogens. Here the authors show that in the absence of NKR-P1B, pneumococcal infection is more severe because KO AM have increased rates of lipid surfactant uptake and reduced anti-microbial function.
