Communications Biology (May 2021)

Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity

  • Dongsheng Li,
  • Min-Hsuan Lin,
  • Daniel J. Rawle,
  • Hongping Jin,
  • Zhonglan Wu,
  • Lu Wang,
  • Mary Lor,
  • Mazhar Hussain,
  • John Aaskov,
  • David Harrich

DOI
https://doi.org/10.1038/s42003-021-02064-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed to make antiviral DIPs for other RNA viruses.