PLoS ONE (Jan 2019)

Influence of hepatic fibrosis and inflammation: Correlation between histopathological changes and Gd-EOB-DTPA-enhanced MR imaging.

  • N Verloh,
  • U Probst,
  • K Utpatel,
  • F Zeman,
  • F Brennfleck,
  • J M Werner,
  • C Fellner,
  • C Stroszczynski,
  • M Evert,
  • P Wiggermann,
  • M Haimerl

DOI
https://doi.org/10.1371/journal.pone.0215752
Journal volume & issue
Vol. 14, no. 5
p. e0215752

Abstract

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ObjectiveTo evaluate the influence of an active inflammatory process in the liver on Gd-EOB-DTPA-enhanced MR imaging in patients with different degrees of fibrosis/cirrhosis.Material and methodsOverall, a number of 91 patients (61 men and 30 women; mean age 58 years) were included in this retrospective study. The inclusion criteria for this study were Gd-EOB-DTPA-enhanced MRI of the liver and histopathological evaluation of fibrotic and inflammatory changes. T1-weighted VIBE sequences of the liver with fat suppression were evaluated to determine the relative signal change (RE) between native and hepatobiliary phase (20min). In simple and multiple linear regression analyses, the influence of liver fibrosis/cirrhosis (Ishak score) and the histopathological degree of hepatitis (Modified Hepatic Activity Index, mHAI) on RE were evaluated.ResultsRE decreased significantly with increasing liver fibrosis/cirrhosis (p ConclusionThe results of this study suggest that the MR-based hepatic enhancement index RE is not only influenced by the degree of fibrosis, but also by the degree of inflammation.