Nature Communications (Jan 2022)
Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
- Young-Il Kim,
- Kwang-Min Yu,
- June-Young Koh,
- Eun-Ha Kim,
- Se-Mi Kim,
- Eun Ji Kim,
- Mark Anthony B. Casel,
- Rare Rollon,
- Seung-Gyu Jang,
- Min-Suk Song,
- Su-Jin Park,
- Hye Won Jeong,
- Eung-Gook Kim,
- Ok-Jun Lee,
- Yong-Dae Kim,
- Younho Choi,
- Shin-Ae Lee,
- Youn Jung Choi,
- Su-Hyung Park,
- Jae U. Jung,
- Young Ki Choi
Affiliations
- Young-Il Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Kwang-Min Yu
- College of Medicine and Medical Research Institute, Chungbuk National University
- June-Young Koh
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
- Eun-Ha Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Se-Mi Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Eun Ji Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Mark Anthony B. Casel
- College of Medicine and Medical Research Institute, Chungbuk National University
- Rare Rollon
- College of Medicine and Medical Research Institute, Chungbuk National University
- Seung-Gyu Jang
- College of Medicine and Medical Research Institute, Chungbuk National University
- Min-Suk Song
- College of Medicine and Medical Research Institute, Chungbuk National University
- Su-Jin Park
- Division of Life Science, Research Institute of Life Science, Gyeongsang National University
- Hye Won Jeong
- College of Medicine and Medical Research Institute, Chungbuk National University
- Eung-Gook Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Ok-Jun Lee
- College of Medicine and Medical Research Institute, Chungbuk National University
- Yong-Dae Kim
- College of Medicine and Medical Research Institute, Chungbuk National University
- Younho Choi
- Cancer Biology Department and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic
- Shin-Ae Lee
- Cancer Biology Department and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic
- Youn Jung Choi
- Cancer Biology Department and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic
- Su-Hyung Park
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
- Jae U. Jung
- Cancer Biology Department and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic
- Young Ki Choi
- College of Medicine and Medical Research Institute, Chungbuk National University
- DOI
- https://doi.org/10.1038/s41467-021-27717-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Here, Kim et al. characterize SARS-CoV-2 infection in juvenile, young, and old aged ferrets to provide a further understanding of differences in COVID-19 severity in humans at different ages. Aged ferrets have higher viral loads, shed virus longer, and mimic the transcriptomic profile of severely infected patients.
