Nature Communications (Apr 2016)
Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
- Hamid Nikbakht,
- Eshini Panditharatna,
- Leonie G. Mikael,
- Rui Li,
- Tenzin Gayden,
- Matthew Osmond,
- Cheng-Ying Ho,
- Madhuri Kambhampati,
- Eugene I. Hwang,
- Damien Faury,
- Alan Siu,
- Simon Papillon-Cavanagh,
- Denise Bechet,
- Keith L. Ligon,
- Benjamin Ellezam,
- Wendy J. Ingram,
- Caedyn Stinson,
- Andrew S. Moore,
- Katherine E. Warren,
- Jason Karamchandani,
- Roger J. Packer,
- Nada Jabado,
- Jacek Majewski,
- Javad Nazarian
Affiliations
- Hamid Nikbakht
- Department of Human Genetics, McGill University
- Eshini Panditharatna
- Research Center for Genetic Medicine, Children’s National Health System
- Leonie G. Mikael
- Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute
- Rui Li
- Department of Human Genetics, McGill University
- Tenzin Gayden
- Department of Human Genetics, McGill University
- Matthew Osmond
- Department of Human Genetics, McGill University
- Cheng-Ying Ho
- Division of Pathology, Children’s National Health System
- Madhuri Kambhampati
- Research Center for Genetic Medicine, Children’s National Health System
- Eugene I. Hwang
- Center for Cancer and Blood Disorders, Children’s National Health System
- Damien Faury
- Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute
- Alan Siu
- The Department of Neurological Surgery, George Washington University School of Medicine and Health Sciences
- Simon Papillon-Cavanagh
- Department of Human Genetics, McGill University
- Denise Bechet
- Department of Human Genetics, McGill University
- Keith L. Ligon
- Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute
- Benjamin Ellezam
- Department of Pathology, CHU Ste-Justine, Université de Montréal
- Wendy J. Ingram
- UQ Child Health Research Centre, The University of Queensland
- Caedyn Stinson
- University of Queensland Diamantina Institute, The University of Queensland
- Andrew S. Moore
- UQ Child Health Research Centre, The University of Queensland
- Katherine E. Warren
- National Cancer Institute, National Institute of Health
- Jason Karamchandani
- Department of Pathology, Montreal Neurological Hospital, McGill University
- Roger J. Packer
- Brain Tumour Institute, Center for Neuroscience and Behavioral Medicine, Children’s National Health System
- Nada Jabado
- Department of Human Genetics, McGill University
- Jacek Majewski
- Department of Human Genetics, McGill University
- Javad Nazarian
- Research Center for Genetic Medicine, Children’s National Health System
- DOI
- https://doi.org/10.1038/ncomms11185
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise first in tumorigenesis followed by a specific invariable sequence of driver mutations, which are homogeneously distributed across the tumour mass.
