Nature Communications (Jun 2021)
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
- A. Rose Brannon,
- Gowtham Jayakumaran,
- Monica Diosdado,
- Juber Patel,
- Anna Razumova,
- Yu Hu,
- Fanli Meng,
- Mohammad Haque,
- Justyna Sadowska,
- Brian J. Murphy,
- Tessara Baldi,
- Ian Johnson,
- Ryan Ptashkin,
- Maysun Hasan,
- Preethi Srinivasan,
- Anoop Balakrishnan Rema,
- Ivelise Rijo,
- Aaron Agarunov,
- Helen Won,
- Dilmi Perera,
- David N. Brown,
- Aliaksandra Samoila,
- Xiaohong Jing,
- Erika Gedvilaite,
- Julie L. Yang,
- Dennis P. Stephens,
- Jenna-Marie Dix,
- Nicole DeGroat,
- Khedoudja Nafa,
- Aijazuddin Syed,
- Alan Li,
- Emily S. Lebow,
- Anita S. Bowman,
- Donna C. Ferguson,
- Ying Liu,
- Douglas A. Mata,
- Rohit Sharma,
- Soo-Ryum Yang,
- Tejus Bale,
- Jamal K. Benhamida,
- Jason C. Chang,
- Snjezana Dogan,
- Meera R. Hameed,
- Jaclyn F. Hechtman,
- Christine Moung,
- Dara S. Ross,
- Efsevia Vakiani,
- Chad M. Vanderbilt,
- JinJuan Yao,
- Pedram Razavi,
- Lillian M. Smyth,
- Sarat Chandarlapaty,
- Gopa Iyer,
- Wassim Abida,
- James J. Harding,
- Benjamin Krantz,
- Eileen O’Reilly,
- Helena A. Yu,
- Bob T. Li,
- Charles M. Rudin,
- Luis Diaz,
- David B. Solit,
- Maria E. Arcila,
- Marc Ladanyi,
- Brian Loomis,
- Dana Tsui,
- Michael F. Berger,
- Ahmet Zehir,
- Ryma Benayed
Affiliations
- A. Rose Brannon
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Gowtham Jayakumaran
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Monica Diosdado
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Juber Patel
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Anna Razumova
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Yu Hu
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Fanli Meng
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Mohammad Haque
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Justyna Sadowska
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Brian J. Murphy
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Tessara Baldi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ian Johnson
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Ryan Ptashkin
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Maysun Hasan
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Preethi Srinivasan
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Anoop Balakrishnan Rema
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ivelise Rijo
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Aaron Agarunov
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Helen Won
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Dilmi Perera
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- David N. Brown
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Aliaksandra Samoila
- Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center
- Xiaohong Jing
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Erika Gedvilaite
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Julie L. Yang
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Dennis P. Stephens
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Jenna-Marie Dix
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Nicole DeGroat
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Khedoudja Nafa
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Aijazuddin Syed
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Alan Li
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Emily S. Lebow
- Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center
- Anita S. Bowman
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Donna C. Ferguson
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ying Liu
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Douglas A. Mata
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Rohit Sharma
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Soo-Ryum Yang
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Tejus Bale
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Jamal K. Benhamida
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Jason C. Chang
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Snjezana Dogan
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Meera R. Hameed
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Jaclyn F. Hechtman
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Christine Moung
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Dara S. Ross
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Efsevia Vakiani
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Chad M. Vanderbilt
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- JinJuan Yao
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Pedram Razavi
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Lillian M. Smyth
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Sarat Chandarlapaty
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Gopa Iyer
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Wassim Abida
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- James J. Harding
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Benjamin Krantz
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Eileen O’Reilly
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Helena A. Yu
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Bob T. Li
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Charles M. Rudin
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Luis Diaz
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- David B. Solit
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Maria E. Arcila
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Marc Ladanyi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Brian Loomis
- Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Dana Tsui
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Michael F. Berger
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ahmet Zehir
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ryma Benayed
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-24109-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Liquid biopsies allow the non-invasive detection of somatic mutations from tumours. Here, the authors develop and test MSK-ACCESS, an NGS-based clinical assay for identifying low frequency mutations in 129 genes and describe how it benefits patients in the clinic.
