Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
Estelle Sfecci,
Thierry Lacour,
Philippe Amade,
Mohamed Mehiri
Affiliations
Estelle Sfecci
Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France
Thierry Lacour
Biopreserv, 4 traverse Dupont, 06130 Grasse, France
Philippe Amade
Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France
Mohamed Mehiri
Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France
Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins have been isolated from Poecilosclerida marine sponges. In this review, we will explore the chemodiversity of tri- and pentacyclic guanidine alkaloids. NMR and MS data tools will also be provided, and an overview of the wide range of bioactivities of crambescidins and batzelladines derivatives will be given.
