Nature Communications (Mar 2023)
Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease
- Themis Thoudam,
- Dipanjan Chanda,
- Jung Yi Lee,
- Min-Kyo Jung,
- Ibotombi Singh Sinam,
- Byung-Gyu Kim,
- Bo-Yoon Park,
- Woong Hee Kwon,
- Hyo-Jeong Kim,
- Myeongjin Kim,
- Chae Won Lim,
- Hoyul Lee,
- Yang Hoon Huh,
- Caroline A. Miller,
- Romil Saxena,
- Nicholas J. Skill,
- Nazmul Huda,
- Praveen Kusumanchi,
- Jing Ma,
- Zhihong Yang,
- Min-Ji Kim,
- Ji Young Mun,
- Robert A. Harris,
- Jae-Han Jeon,
- Suthat Liangpunsakul,
- In-Kyu Lee
Affiliations
- Themis Thoudam
- Research Institute of Aging and Metabolism, Kyungpook National University
- Dipanjan Chanda
- Research Institute of Aging and Metabolism, Kyungpook National University
- Jung Yi Lee
- Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital
- Min-Kyo Jung
- Neural Circuit Research Group, Korea Brain Research Institute
- Ibotombi Singh Sinam
- Bio-Medical Research Institute, Kyungpook National University Hospital
- Byung-Gyu Kim
- Center for Genomic Integrity, Institute for Basic Science (IBS)
- Bo-Yoon Park
- Research Institute of Aging and Metabolism, Kyungpook National University
- Woong Hee Kwon
- Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital
- Hyo-Jeong Kim
- Electron Microscopy Research Center, Korea Basic Science Institute
- Myeongjin Kim
- Research Institute of Aging and Metabolism, Kyungpook National University
- Chae Won Lim
- Bio-Medical Research Institute, Kyungpook National University Hospital
- Hoyul Lee
- Research Institute of Aging and Metabolism, Kyungpook National University
- Yang Hoon Huh
- Electron Microscopy Research Center, Korea Basic Science Institute
- Caroline A. Miller
- Electron Microscopy Core, Indiana University School of Medicine
- Romil Saxena
- Department of Pathology and Laboratory Medicine, Indiana University School of Medicine
- Nicholas J. Skill
- Department of Surgery, Louisiana State University Health Science Center
- Nazmul Huda
- Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine
- Praveen Kusumanchi
- Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine
- Jing Ma
- Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine
- Zhihong Yang
- Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine
- Min-Ji Kim
- Department of Internal Medicine, Kyungpook National University Chilgok Hospital
- Ji Young Mun
- Neural Circuit Research Group, Korea Brain Research Institute
- Robert A. Harris
- Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
- Jae-Han Jeon
- Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital
- Suthat Liangpunsakul
- Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine
- In-Kyu Lee
- Research Institute of Aging and Metabolism, Kyungpook National University
- DOI
- https://doi.org/10.1038/s41467-023-37214-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Ca2+ overload-induced mitochondrial dysfunction is considered a contributing factor alcohol-associated liver disease pathogenesis. Here the authors report that PDK4 promotes Ca2 + -channelling complex formation at the endoplasmic reticulum-mitochondria contact sites, which contributes to the pathogenesis of alcohol-associated liver disease in studies with male mouse and hepatocyte models.
