Short-term effects of intravenous batroxobin in treatment of sudden sensorineural hearing loss: a propensity score-matched study

Mengzhu Jiang; Mengzhu Jiang; Huping Huang; Huping Huang; Lingyun Mei; Lingyun Mei; Lingyun Mei; Chufeng He; Chufeng He; Chufeng He; Xinzhang Cai; Xinzhang Cai; Xinzhang Cai; Lu Jiang; Lu Jiang; Lu Jiang; Hong Wu; Hong Wu; Hong Wu; Xin Wang; Xin Wang; Xuewen Wu; Xuewen Wu; Xuewen Wu

doi:10.3389/fneur.2023.1102297

Frontiers in Neurology (Apr 2023)

Short-term effects of intravenous batroxobin in treatment of sudden sensorineural hearing loss: a propensity score-matched study

Mengzhu Jiang,
Mengzhu Jiang,
Huping Huang,
Huping Huang,
Lingyun Mei,
Lingyun Mei,
Lingyun Mei,
Chufeng He,
Chufeng He,
Chufeng He,
Xinzhang Cai,
Xinzhang Cai,
Xinzhang Cai,
Lu Jiang,
Lu Jiang,
Lu Jiang,
Hong Wu,
Hong Wu,
Hong Wu,
Xin Wang,
Xin Wang,
Xuewen Wu,
Xuewen Wu,
Xuewen Wu

Affiliations

Mengzhu Jiang: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Mengzhu Jiang: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Huping Huang: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Huping Huang: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Lingyun Mei: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Lingyun Mei: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Lingyun Mei: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Chufeng He: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Chufeng He: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Chufeng He: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Xinzhang Cai: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xinzhang Cai: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Xinzhang Cai: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Lu Jiang: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Lu Jiang: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Lu Jiang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Hong Wu: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Hong Wu: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Hong Wu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Xin Wang: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xin Wang: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Xuewen Wu: Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xuewen Wu: Province Key Laboratory of Otolaryngology Critical Diseases, Changsha, Hunan, China
Xuewen Wu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fneur.2023.1102297
Journal volume & issue: Vol. 14

Abstract

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BackgroundSudden sensorineural hearing loss (SSNHL) can cause great panic in patients. Whether it is advantageous to add intravenous batroxobin in the treatment of SSNHL remains to be determined. This study aimed to compare the short-term efficacy of therapy combined with intravenous batroxobin and that without intravenous batroxobin in SSNHL patients.MethodsThis retrospective study harvested the data of SSNHL patients hospitalized in our department from January 2008 to April 2021. The hearing levels on the admitted day (before treatment) and the discharge day were considered pre-treatment hearing and post-treatment hearing, respectively. The hearing gain was the difference value of pre-treatment hearing and post-treatment hearing. We used Siegel's criteria and the Chinese Medical Association of Otolaryngology (CMAO) criteria to evaluate hearing recovery. The complete recovery rate, overall effective rate, and hearing gain at each frequency were considered outcomes. Propensity score matching (PSM) was conducted to balance the baseline characteristics between the batroxobin group and the non-batroxobin group. Sensitivity analysis was carried out in flat-type and total-deafness SSNHL patients.ResultsDuring the study period, 657 patients with SSNHL were admitted to our department. Among them, a total of 274 patients met the enrolled criteria of our study. After PSM, 162 patients (81 in each group) were included in the analysis. Once the hospitalized treatment was completed, the patients would be discharged the next day. Logistic regression analysis of the propensity score-matched cohort indicated that both the complete recovery rates [Siegel's criteria, OR: 0.734, 95% CI: 0.368–1.466, p = 0.381; CMAO criteria, OR: 0.879, 95% CI: 0.435–1.777, p = 0.720] and the overall effective rates [Siegel's criteria and CMAO criteria, OR: 0.741, 95% CI: 0.399–1.378, p = 0.344] were not significantly different between the two treatment groups. Sensitivity analysis has shown similar results. For flat-type and total-deafness SSNHL patients, no significant difference was found in post-treatment hearing gain at each frequency between the two groups after PSM.ConclusionThere was no significant difference in short-term hearing outcomes between treatment with batroxobin and treatment without batroxobin in SSNHL patients by Siegel's and CMAO criteria after PSM. Future studies for better therapy regimens of SSNHL are still needed.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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