The architecture of the Schizosaccharomyces pombe CCR4-NOT complex

Marta Ukleja; Jorge Cuellar; Aleksandra Siwaszek; Joanna M. Kasprzak; Mariusz Czarnocki-Cieciura; Janusz M. Bujnicki; Andrzej Dziembowski; Jose M. Valpuesta

doi:10.1038/ncomms10433

Nature Communications (Jan 2016)

The architecture of the Schizosaccharomyces pombe CCR4-NOT complex

Marta Ukleja,
Jorge Cuellar,
Aleksandra Siwaszek,
Joanna M. Kasprzak,
Mariusz Czarnocki-Cieciura,
Janusz M. Bujnicki,
Andrzej Dziembowski,
Jose M. Valpuesta

Affiliations

Marta Ukleja: Institute of Biochemistry and Biophysics, Polish Academy of Sciences
Jorge Cuellar: Department of Structure of Macromolecules, Centro Nacional de Biotecnología (CNB-CSIC)
Aleksandra Siwaszek: Institute of Biochemistry and Biophysics, Polish Academy of Sciences
Joanna M. Kasprzak: Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw
Mariusz Czarnocki-Cieciura: Institute of Biochemistry and Biophysics, Polish Academy of Sciences
Janusz M. Bujnicki: Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw
Andrzej Dziembowski: Institute of Biochemistry and Biophysics, Polish Academy of Sciences
Jose M. Valpuesta: Department of Structure of Macromolecules, Centro Nacional de Biotecnología (CNB-CSIC)

DOI: https://doi.org/10.1038/ncomms10433
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the previously reported functions of the complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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