Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus

Neelakshi R. Jog; Judith A. James; Judith A. James

doi:10.3389/fimmu.2020.623944

Frontiers in Immunology (Feb 2021)

Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus

Neelakshi R. Jog,
Judith A. James,
Judith A. James

Affiliations

Neelakshi R. Jog: Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States
Judith A. James: Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States
Judith A. James: Departments of Medicine, Pathology, Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

DOI: https://doi.org/10.3389/fimmu.2020.623944
Journal volume & issue: Vol. 11

Abstract

Read online

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren’s syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

About the journal

Abstract

Keywords