Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?

Abstract

Abstract Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replication to levels below the assay detection limit in the macaque AIDS model. Moreover, different therapeutic regimens applied to the rhesus macaque AIDS model (herein reviewed), including ours, are starting to show the potential to induce, following therapy suspension, conditions reminiscent of a drug-free control of the infection.

Keywords

• Macaque AIDS model
• Functional cure
• Antiretroviral therapy
• Central memory CD4⁺ T-cells
• Maraviroc
• Auranofin
• Buthionine sulfoximine (BSO)
• Anti-reservoir